Article
Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.
Cellular and molecular life sciences : CMLS - 1 Sept 2013
Angata Takashi, Ishii Takeo, Motegi Takashi, Oka Ritsuko, Taylor Rachel E, Soto Paula Campos, Chang Yung-Chi, Secundino Ismael, Gao Cong-Xiao, Ohtsubo Kazuaki, Kitazume Shinobu, Nizet Victor, Varki Ajit, Gemma Akihiko, Kida Kozui, Taniguchi Naoyuki
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. COPD exacerbation, or episodic worsening of symptoms, often results in hospitalization and increased mortality rates. Airway infections by new bacterial strains, such as nontypeable Haemophilus influenzae (NTHi), are a major cause of COPD exacerbation. NTHi express lipooligosaccharides that contain sialic acids, and may...
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