Article
Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.
Respirology (Carlton, Vic.) - 1 May 2017
Ishii Takeo, Angata Takashi, Wan Emily S, Cho Michael H, Motegi Takashi, Gao Congxiao, Ohtsubo Kazuaki, Kitazume Shinobu, Gemma Akihiko, ParÉ Peter D, Lomas David A, Silverman Edwin K, Taniguchi Naoyuki, Kida Kozui
Abstract excerpt
BACKGROUND AND OBJECTIVE: The exacerbation-prone phenotype of COPD is particularly important, as exacerbations lead to poor quality of life and disease progression. We previously found that COPD patients who lack Siglec-14, a myeloid cell protein that recognizes bacteria and triggers inflammatory responses, are less prone to exacerbation. We hypothesized that the variations in other SIGLEC genes could also...
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