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Article

Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999

Ashrafi K, Sinclair D, Gordon J I, Guarente L

Abstract excerpt

Saccharomyces cerevisiae mother cells undergo an aging program that includes morphologic changes, sterility, redistribution of the Sir transcriptional silencing complex from HM loci and telomeres to the nucleolus, alterations in nucleolar architecture, and accumulation of extrachromosomal ribosomal DNA circles (ERCs). We report here that cells starved for nutrients during prolonged periods in stationary phase...

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Identifiers

PMID: 10430902
DOI: 10.1073/pnas.96.16.9100
PMCID: PMC17739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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