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Replication stress as a driver of cellular senescence and aging

22 May 2024

Abstract excerpt

Replication stress refers to slowing or stalling of replication fork progression during DNA synthesis that disrupts faithful copying of the genome. While long considered a nexus for DNA damage, the role of replication stress in aging is under-appreciated. The consequential role of replication stress in promotion of organismal aging phenotypes is evidenced by an extensive list of hereditary accelerated aging...

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PMID: 38777831
DOI: 10.1038/s42003-024-06263-w

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