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A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis

14 Mar 2013

Abstract excerpt

The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo and in vivo. Using a novel mouse model, we tested the potential of GRN510 to limit fibrosis induced by bleomycin in mTERT heterozygous mice. Treatment with...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 23516479
DOI: 10.1371/journal.pone.0058423

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