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Article

Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.

Immunity - 20 Nov 2009

Oldenhove Guillaume, Bouladoux Nicolas, Wohlfert Elizabeth A, Hall Jason A, Chou David, Dos Santos Liliane, O'Brien Shaun, Blank Rebecca, Lamb Erika, Natarajan Sundar, Kastenmayer Robin, Hunter Christopher, Grigg Michael E, Belkaid Yasmine

Abstract excerpt

Using a model of lethal oral infection with Toxoplasma gondii, we examined the fate of both induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses occurring in a tolerogenic-prone environment. We found that during highly T helper 1 (Th1) cell-polarized mucosal immune responses, Treg cell numbers collapsed via multiple pathways, including blockade of Treg cell induction and...

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Identifiers

PMID: 19896394
DOI: 10.1016/j.immuni.2009.10.001
PMCID: PMC2814877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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