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Article

Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program.

Obesity (Silver Spring, Md.) - 1 Sept 2013

Pan Qing, Delahanty Linda M, Jablonski Kathleen A, Knowler William C, Kahn Steven E, Florez Jose C, Franks Paul W

Abstract excerpt

OBJECTIVE: To assess associations and genotype × treatment interactions for melanocortin 4 receptor (MC4R) locus variants and obesity-related traits. DESIGN AND METHODS: Diabetes prevention program (DPP) participants (N = 3,819, of whom 3,356 were genotyped for baseline and 3,234 for longitudinal analyses) were randomized into intensive lifestyle modification (diet, exercise, weight loss), metformin or placebo...

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Identifiers

PMID: 23512951
DOI: 10.1002/oby.20459
PMCID: PMC4023472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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