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Article

A nanogram dose of the CYP3A probe substrate midazolam to evaluate drug interactions.

Clinical pharmacology and therapeutics - 1 Jun 2013

Halama B, Hohmann N, Burhenne J, Weiss J, Mikus G, Haefeli W E

Abstract excerpt

The objective of the study was to establish an in vivo method for assessing cytochrome P450 3A (CYP3A) activity using therapeutically inert nanogram doses of midazolam. We administered four escalating single doses of oral midazolam (0.0001-3 mg) to 12 healthy participants, stratified according to CYP3A5 carrier status, to assess pharmacokinetics linearity. We then evaluated the interactions with the CYP3A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23511711
DOI: 10.1038/clpt.2013.27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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