Positive association between--1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users.

doi:10.1016/j.neulet.2013.02.049

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Article

Positive association between--1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users.

Neuroscience letters - 29 Apr 2013

Xie Xiaohu, Xu Limin, Liu Huifen, Chen Weisheng, Zhuang Dingding, Zhang Jianbing, Duan Shiwei, Zhou Wenhua

Abstract excerpt

By balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (DBH) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction. DBH -1021C/T (rs1611115) is a functional variant with strong correlation with plasma DBH activity and several nerval and psychic disorders. In the present study, we have collected 333 male cases with heroin addiction...

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PMID: 23510745
DOI: 10.1016/j.neulet.2013.02.049

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