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Article

Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls.

Pharmacogenomics - 1 Jan 2018

Randesi Matthew, van den Brink Wim, Levran Orna, Yuferov Vadim, Blanken Peter, van Ree Jan M, Ott Jurg, Kreek Mary Jeanne

Abstract excerpt

AIM: To determine whether specific dopaminergic system gene variants are associated with opioid dependence. PATIENTS & METHODS: Subjects included 153 healthy controls, 163 opioid exposed, but not dependent and 281 opioid dependent. Genotypes of 90 variants in 13 genes were examined. RESULTS: The most significant results were obtained for DA β-hydroxylase variants, rs2073837 and rs1611131, which were associated...

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Share to Analgesics, Opioid
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Share to Polymorphism, Single Nucleotide
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Source

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Identifiers

PMID: 29210332
DOI: 10.2217/pgs-2017-0134
PMCID: PMC6826863

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