Article
The human gene connectome as a map of short cuts for morbid allele discovery.
Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2013
Itan Yuval, Zhang Shen-Ying, Vogt Guillaume, Abhyankar Avinash, Herman Melina, Nitschke Patrick, Fried Dror, Quintana-Murci Lluis, Abel Laurent, Casanova Jean-Laurent
Abstract excerpt
High-throughput genomic data reveal thousands of gene variants per patient, and it is often difficult to determine which of these variants underlies disease in a given individual. However, at the population level, there may be some degree of phenotypic homogeneity, with alterations of specific physiological pathways underlying the pathogenesis of a particular disease. We describe here the human gene connectome...
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