Article

SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cells

2025-11-14

Abstract excerpt

Glucocorticoids are a widely used, potent class of anti-inflammatory drugs that modulate the expression of hundreds of genes across the genome. Although the glucocorticoid response is primarily carried out by the glucocorticoid receptor (NR3C1, a.k.a. GR), there are many glucocorticoid receptor co-factors that are also essential to the downstream effects. To identify novel factors necessary for the glucocorticoid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac3608fc-6666-5461-918a-84fe39a1666a
DOI: 10.1101/2025.11.13.688306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cellsDOI 10.1101/2025.11.13.688306Read

Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory EffectsSemantic proximity Read

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid ReceptorSemantic proximity Read

Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFα Coregulate Gene Expression In Vitro and In VivoSemantic proximity Read

RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells.Semantic proximity Read

Glucocorticoids regulate the human non-coding genomeSemantic proximity Read

Comprehensive overview of the structure and regulation of the glucocorticoid receptor.Semantic proximity Read

How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoidsSemantic proximity Read

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious DiseasesSemantic proximity Read

Glucocorticoid receptor collaborates with pioneer factors and AP-1 to execute genome-wide regulationSemantic proximity Read

Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?Semantic proximity Read

Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptorSemantic proximity Read

Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics eraSemantic proximity Read