Article
Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.
Molecular cell - 4 May 2017
Yang Feng, Ma Qi, Liu Zhijie, Li Wenbo, Tan Yuliang, Jin Chunyu, Ma Wubin, Hu Yiren, Shen Jia, Ohgi Kenneth A, Telese Francesca, Liu Wen, Rosenfeld Michael G
Abstract excerpt
The molecular mechanisms underlying the opposing functions of glucocorticoid receptors (GRs) and estrogen receptor α (ERα) in breast cancer development remain poorly understood. Here we report that, in breast cancer cells, liganded GR represses a large ERα-activated transcriptional program by binding, in trans, to ERα-occupied enhancers. This abolishes effective activation of these enhancers and their cognate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.