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Article

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2013

Cheshenko Natalia, Trepanier Janie B, Stefanidou Martha, Buckley Niall, Gonzalez Pablo, Jacobs William, Herold Betsy C

Abstract excerpt

HSV triggers intracellular calcium release to promote viral entry. We hypothesized that Akt signaling induces the calcium responses and contributes to HSV entry. Exposure of human cervical and primary genital tract epithelial, neuronal, or keratinocyte cells to HSV serotype 2 resulted in rapid phosphorylation of Akt. Silencing of Akt with small interfering RNA prevented the calcium responses, blocked viral entry,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 23507869
DOI: 10.1096/fj.12-220285
PMCID: PMC3688744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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