Article

Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

2023-09-05

Abstract excerpt

Establishing a non-productive quiescent/silent infection within monocytes is essential for spread of human cytomegalovirus (HCMV). Yet, how HCMV establishes a quiescent infection in monocytes remains unclear. US28 is a viral G protein-coupled receptor (GPCR) essential for silent infections within cells of the myeloid lineage. We found virion-associated US28 was rapidly delivered to monocytes, while de novo synthe...

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Literature Corpus work: e382e210-a44f-52d6-a77f-a536609c772d
DOI: 10.1101/2023.09.05.556359

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