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Article

Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.

PloS one - 1 Jan 2011

Kim Yuri, Hollenbaugh Joseph A, Kim Dong-Hyun, Kim Baek

Abstract excerpt

The PI3K/Akt pathway regulates various stress-related cellular responses such as cell survival, cell proliferation, metabolism and protein synthesis. Many cancer cell types display the activation of this pathway, and compounds inhibiting this cell survival pathway have been extensively evaluated as anti-cancer agents. In addition to cancers, several human viruses, such as HTLV, HPV, HCV and HIV-1, also modulate...

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Source

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Identifiers

PMID: 21765914
DOI: 10.1371/journal.pone.0021781
PMCID: PMC3134463

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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