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Article

Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.

PloS one - 5 Mar 2010

MacLeod Iain J, Minson Tony

Abstract excerpt

The envelope of HSV-1 contains a number of glycoproteins, four of which are essential for virus entry. Virus particles lacking gB, gD, gH or gL are entry-defective, although these viruses retain the ability to bind to the plasma membrane via the remaining glycoproteins. Soluble forms of gD have been shown to trigger the nuclear translocation of the NF-kappaB transcriptional complex in addition to stimulating the...

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Identifiers

PMID: 20221426
DOI: 10.1371/journal.pone.0009560
PMCID: PMC2832691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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