Article
B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain.
PloS one - 1 Jan 2013
Hägglund Maria G A, Roshanbin Sahar, Löfqvist Erik, Hellsten Sofie V, Nilsson Victor C O, Todkar Aniruddha, Zhu Yinan, Stephansson Olga, Drgonova Jana, Uhl George R, Schiöth Helgi B, Fredriksson Robert
Abstract excerpt
The B(0)AT2 protein is a product of the SLC6A15 gene belonging to the SLC6 subfamily and has been shown to be a transporter of essential branched-chain amino acids. We aimed to further characterize the B(0)AT2 transporter in CNS, and to use Slc6a15 knock out (KO) mice to investigate whether B(0)AT2 is important for mediating the anorexigenic effect of leucine. We used the Slc6a15 KO mice to investigate the role...
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