Article
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.
PloS one - 1 Jan 2013
Tsai Vicky Wang-Wei, Macia Laurence, Johnen Heiko, Kuffner Tamara, Manadhar Rakesh, Jørgensen Sebastian Beck, Lee-Ng Ka Ki Michelle, Zhang Hong Ping, Wu Liyun, Marquis Christopher Peter, Jiang Lele, Husaini Yasmin, Lin Shu, Herzog Herbert, Brown David A, Sainsbury Amanda, Breit Samuel N
Abstract excerpt
The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body weight and basal metabolic rate. MIC-1/GDF15 gene knockout mice (MIC-1(-/-)) weighed more and had increased...
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