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Article

Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse.

The Journal of biological chemistry - 29 Jul 2011

Bröer Angelika, Juelich Torsten, Vanslambrouck Jessica M, Tietze Nadine, Solomon Peter S, Holst Jeff, Bailey Charles G, Rasko John E J, Bröer Stefan

Abstract excerpt

Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid transporters. To understand the role of epithelial neutral amino acid uptake in whole body homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0) amino acid transporter B(0)AT1 (Slc6a19). A general neutral aminoaciduria was observed similar to human Hartnup disorder which is caused by mutations in SLC6A19....

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Identifiers

PMID: 21636576
DOI: 10.1074/jbc.M111.241323
PMCID: PMC3143628

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ATF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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