Article
The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry.
Obesity (Silver Spring, Md.) - 1 Jan 2013
Deliard Sandra, Panossian Saarene, Mentch Frank D, Kim Cecilia E, Hou Cuiping, Frackelton Edward C, Bradfield Jonathan P, Glessner Joseph T, Zhang Haitao, Wang Kai, Sleiman Patrick M A, Chiavacci Rosetta M, Berkowitz Robert I, Hakonarson Hakon, Zhao Jianhua, Grant Struan F A
Abstract excerpt
OBJECTIVE: Common variation at the loci harboring fat mass and obesity (FTO), melanocortin receptor 4 (MC4R), and transmembrane protein 18 (TMEM18) is consistently reported as being statistically most strongly associated with obesity. Investigations if these loci also harbor rarer missense variants that confer substantially higher risk of common childhood obesity in African American (AA) children were conducted....
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