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Article

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli.

Nature biotechnology - 1 Apr 2013

Gat-Viks Irit, Chevrier Nicolas, Wilentzik Roni, Eisenhaure Thomas, Raychowdhury Raktima, Steuerman Yael, Shalek Alex K, Hacohen Nir, Amit Ido, Regev Aviv

Abstract excerpt

Individual genetic variation affects gene responsiveness to stimuli, often by influencing complex molecular circuits. Here we combine genomic and intermediate-scale transcriptional profiling with computational methods to identify variants that affect the responsiveness of genes to stimuli (responsiveness quantitative trait loci or reQTLs) and to position these variants in molecular circuit diagrams. We apply this...

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Identifiers

PMID: 23503680
DOI: 10.1038/nbt.2519
PMCID: PMC3622156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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