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Article

RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.

Cell reports - 14 Apr 2015

Takashima Ken, Oshiumi Hiroyuki, Takaki Hiromi, Matsumoto Misako, Seya Tsukasa

Abstract excerpt

MDA5 is a cytoplasmic viral double-stranded RNA (dsRNA) sensor and triggers type I interferon (IFN) production. MDA5 assembles along viral dsRNA, leading to the formation of an MDA5 filament required for activating the MAVS adaptor. A recent study has revealed that PP1α and PP1γ phosphatases are responsible for dephosphorylating MDA5 and are essential for its activation. Here, we identified RIO kinase 3 (RIOK3)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-Induced Helicase, IFIH1

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Source

Identifiers

PMID: 25865883
DOI: 10.1016/j.celrep.2015.03.027

Genes

RIOK3
MAVS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.PMID 25865883Read ↗

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