Article
Evaluation of chromosome 11p imbalances in aniridia and Wilms tumor patients.
American journal of medical genetics. Part A - 1 May 2013
Busch Maike, Leube Barbara, Thiel Anne, Schanze Ina, Beier Manfred, Royer-Pokora Brigitte
Abstract excerpt
Newborn sporadic aniridia patients with an 11p13 deletion including the WT1 gene have an increased risk to develop Wilms tumor. At present a risk for Wilms tumor cannot be estimated in patients with deletions not extending into, but ending close to WT1. Therefore, it is important to determine the distance of deletion endpoints from the WT1 gene and survey these patients for a longer follow-up time to obtain a...
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