Article
Polymerase chain reaction-based risk assessment for Wilms tumor in sporadic aniridia.
American journal of ophthalmology - 1 May 1998
Gupta S K, De Becker I, Guernsey D L, Neumann P E
Abstract excerpt
PURPOSE: Sporadic cases of aniridia have a 30% risk for the development of Wilms tumor. Current guidelines for sporadic aniridia recommend screening by renal ultrasonography for the presence of tumors every 6 months until age 5 years. Deletions of chromosome 11p13 that affect both PAX6 (aniridia)...
Topics
- Aniridia
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- DNA
- DNA-Binding Proteins
- Eye Proteins
- Genes, Wilms Tumor
- Genotype
- Homeodomain Proteins
- Humans
- Kidney Neoplasms
- PAX6 Transcription Factor
- Paired Box Transcription Factors
- Polymerase Chain Reaction
- Repressor Proteins
- Risk Assessment
- Sensitivity and Specificity
- Transcription Factors