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Article

Inhibition of the canonical Wnt pathway by high glucose can be reversed by parathyroid hormone-related protein in osteoblastic cells.

Journal of cellular biochemistry - 1 Aug 2013

López-Herradón Ana, Portal-Núñez Sergio, García-Martín Adela, Lozano Daniel, Pérez-Martínez Francisco C, Ceña Valentín, Esbrit Pedro

Abstract excerpt

Recent in vivo findings suggest that the bone sparing effect of parathyroid hormone-related protein (PTHrP) in diabetic mice might occur at least in part through targeting a suppressed Wnt/β-catenin pathway in osteoblasts. We here aimed to examine the inhibitory action of a high glucose environment on specific components of the canonical Wnt pathway, and the putative compensatory effects of PTHrP, in osteoblastic...

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Identifiers

PMID: 23494914
DOI: 10.1002/jcb.24535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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