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Article

Short- and long-term exposure to high glucose induces unique transcriptional changes in osteoblasts in vitro

14 May 2024

Abstract excerpt

Bone is increasingly recognized as a target for diabetic complications. In order to evaluate the direct effects of high glucose on bone, we investigated the global transcriptional changes induced by hyperglycemia in osteoblasts in vitro. Rat bone marrow-derived mesenchymal stromal cells were differentiated into osteoblasts for 10 days, and prior to analysis, they were exposed to hyperglycemia (25 mM) for the...

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PMID: 38742438
DOI: 10.1242/bio.060239

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