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Article

High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing.

The American journal of pathology - 1 Oct 2009

Alblowi Jazia, Kayal Rayyan A, Siqueira Michelle, Siqueria Michelle, McKenzie Erin, Krothapalli Nanarao, McLean Jody, Conn Jason, Nikolajczyk Barbara, Einhorn Thomas A, Gerstenfeld Louis, Graves Dana T

Abstract excerpt

Diabetes interferes with fracture repair; therefore, we investigated mechanisms of impaired fracture healing in a model of multiple low-dose streptozotocin-induced diabetes. Microarray and gene set enrichment analysis revealed an up-regulation of gene sets related to inflammation, including tumor necrosis factor (TNF) signaling in the diabetic group, when cartilage is being replaced by bone on day 16, but not on...

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Share to Cartilage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19745063
DOI: 10.2353/ajpath.2009.090148
PMCID: PMC2751554

Genes

TNF
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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