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Article

FOXOs attenuate bone formation by suppressing Wnt signaling.

The Journal of clinical investigation - 1 Aug 2013

Iyer Srividhya, Ambrogini Elena, Bartell Shoshana M, Han Li, Roberson Paula K, de Cabo Rafael, Jilka Robert L, Weinstein Robert S, O'Brien Charles A, Manolagas Stavros C, Almeida Maria

Abstract excerpt

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The hallmarks of skeletal involution with age, on the other hand, are decreased bone formation and increased bone marrow adiposity. These changes are associated with increased oxidative stress and decreased growth factor production, which activate members of the FOXO family of transcription factors. FOXOs in turn attenuate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23867625
DOI: 10.1172/JCI68049
PMCID: PMC3726166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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