Genetic Variants in Membranous Nephropathy

Abstract excerpt

Primary (or idiopathic) membranous nephropathy is an organ-specific autoimmune disease in which circulating antibodies to a conformation-dependent epitope in the target antigen, the M-type receptor for phospholipase A2 (PLA2R), are detectable in up to 80% of patients from various ethnic groups.1,2 It mainly affects older adults and is unusual in that the immune deposits and circulating anti-PLA2R antibodies are...

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