Article
PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Sept 2016
Ramachandran Raja, Kumar Vinod, Kumar Ashwani, Yadav Ashok Kumar, Nada Ritambhra, Kumar Harsha, Kumar Vivek, Rathi Manish, Kohli Harbir Singh, Gupta Krishan Lal, Sakhuja Vinay, Jha Vivekanand
Abstract excerpt
BACKGROUND: Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 genes are associated with PMN. Whether these alleles are associated with the development of anti-PLA2R is unknown. In this prospective study we evaluated anti-PLA2R, enhanced glomerular staining for PLA2R and variations in PLA2R1 and...
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