Article
Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2013
Mak Paul, Chang Cheng, Pursell Bryan, Mercurio Arthur M
Abstract excerpt
Estrogen receptor β (ERβ) promotes the degradation of hypoxia inducible factor 1α (HIF-1α), which contributes to the ability of this hormone receptor to sustain the differentiation of epithelial and carcinoma cells. Although the loss of ERβ and consequent HIF-1 activation occur in prostate cancer with profound consequences, the mechanism by which ERβ promotes the degradation of HIF-1α is unknown. We report that...
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