Article

Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal Cells

2024-12-17

Abstract excerpt

Di(2-ethylhexyl) phthalate (DEHP), a known endocrine-disrupting chemical, is a plasticizer found in many common consumer products. High levels of DEHP exposure have been linked to adverse pregnancy outcomes, yet little is known about how it affects human uterine functions. We previously reported that the estrogen-regulated transcription factor hypoxia-inducible factor 2 alpha (HIF2α) promotes the expression of Rab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36aea4c6-5864-5326-b67c-805f8b21dcd6
DOI: 10.1101/2024.12.12.628185

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal CellsDOI 10.1101/2024.12.12.628185Read

Mono-(2-ethylhexyl) phthalate induces trophoblast hypoxia and mitochondrial dysfunction through HIF-1α-miR-210-3p axis in HTR-8/SVneo cell lineSemantic proximity Read

Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitroSemantic proximity Read

Long-term dietary exposure to a mixture of phthalates enhances estrogen and beta-catenin signaling pathways, leading to endometrial hyperplasia in miceSemantic proximity Read

Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in WomenSemantic proximity Read

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placentaSemantic proximity Read

REPRODUCTIVE TOXICOLOGY: Environmental exposures, fetal testis development and function: phthalates and beyondSemantic proximity Read

Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human PlacentationSemantic proximity Read

DEHP exposure impairs human skeletal muscle cell proliferation in primary culture conditionsSemantic proximity Read

In Vitro Exposure of Human Luteinized Mural Granulosa Cells to Dibutyl Phthalate Affects Global Gene ExpressionSemantic proximity Read

Plasticizer Bis(2-ethylhexyl) Phthalate Causes Meiosis Defects and Decreases Fertilization Ability of Mouse Oocytes in VivoSemantic proximity Read

Estrogen-regulated miRNA-27b is altered by bisphenol A in human endometrial stromal cellsSemantic proximity Read

Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 SignalingSemantic proximity Read