Article
Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2013
Ali Salman, Hirschfeld Aaron F, Mayer Matthew L, Fortuno Edgardo S, Corbett Nathan, Kaplan Maia, Wang Shirley, Schneiderman Julia, Fjell Christopher D, Yan Jin, Akhabir Loubna, Aminuddin Farzian, Marr Nico, Lacaze-Masmonteil Thierry, Hegele Richard G, Becker Allan, Chan-Yeung Moira, Hancock Robert E W, Kollmann Tobias R, Daley Denise, Sandford Andrew J, Lavoie Pascal M, Turvey Stuart E
Abstract excerpt
Respiratory diseases are the most frequent chronic illnesses in babies and children. Although a vigorous innate immune system is critical for maintaining lung health, a balanced response is essential to minimize damaging inflammation. We investigated the functional and clinical impact of human genetic variants in the promoter of NFKBIA, which encodes IκBα, the major negative regulator of NF-κB. In this study, we...
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