Article
Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes.
The Journal of allergy and clinical immunology - 1 Dec 2012
Daley Denise, Park Julie E, He Jian-Qing, Yan Jin, Akhabir Loubna, Stefanowicz Dorota, Becker Allan B, Chan-Yeung Moira, Bossé Yohan, Kozyrskyj Anita L, James Alan L, Musk Arthur W, Laprise Catherine, Hegele Richard G, Paré Peter D, Sandford Andrew J
Abstract excerpt
BACKGROUND: The innate immune system is essential for host survival because of its ability to recognize invading pathogens and mount defensive responses. OBJECTIVES: We sought to identify genetic associations of innate immunity genes with atopy and asthma and interactions with early viral infections (first 12 months of life) in a high-risk birth cohort. METHODS: Three Canadian family-based studies and 1...
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