Article
'Favourable' IL28B polymorphisms are associated with a marked increase in baseline viral load in hepatitis C virus subtype 3a infection and do not predict a sustained virological response after 24 weeks of therapy.
The Journal of general virology - 1 Jun 2013
Bucci Cristina, von Delft Annette, Christian Annabel, Flemming Vicki M, Harrison Abby, Halliday John, Collier Jane, Manganis Chris, Klenerman Paul, Irving William, Barnes Eleanor
Abstract excerpt
IL28B host genetic make-up is known to play a critical role in the outcome of genotype 1 hepatitis C virus (HCV) infection in the context of both primary infection and therapy. However, the role of IL28B in subtype 3a infection remains unclear, and has not yet been assessed in the UK population where subtype 3a is dominant. In this study, we evaluated the role of the IL28B single-nucleotide polymorphism rs8099917...
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