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Article

Apical CFTR expression in human nasal epithelium correlates with lung disease in cystic fibrosis.

PloS one - 1 Jan 2013

van Meegen Marit Arianne, Terheggen-Lagro Suzanne Willemina Julia, Koymans Kirsten Judith, van der Ent Cornelis Korstiaan, Beekman Jeffrey Matthijn

Abstract excerpt

INTRODUCTION: Although most individuals with cystic fibrosis (CF) develop progressive obstructive lung disease, disease severity is highly variable, even for individuals with similar CFTR mutations. Measurements of chloride transport as expression of CFTR function in nasal epithelial cells correlate with pulmonary function and suggest that F508del-CFTR is expressed at the apical membrane. However, an association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

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Share to Microscopy, Confocal

Share to Nasal Mucosa

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Source

Open in PubMed Open full text

Identifiers

PMID: 23483918
DOI: 10.1371/journal.pone.0057617
PMCID: PMC3590182

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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