Article
Decreased expression of the CFTR protein in remodeled human nasal epithelium from non-cystic fibrosis patients.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 1995
Brezillon S, Dupuit F, Hinnrasky J, Marchand V, Kälin N, Tümmler B, Puchelle E
Abstract excerpt
BACKGROUND: In normal adult pseudostratified human nasal surface epithelium, the cystic fibrosis transmembrane conductance regulator (CFTR) is localized to the apical domain of the ciliated cells, whereas in cystic fibrosis (CF), the mutated delta F 508 CFTR exhibits an abnormal cytoplasmic local...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cell Differentiation
- Cystic Fibrosis Transmembrane Conductance Regulator
- Cytoskeletal Proteins
- Desmoplakins
- Epithelial Cells
- Epithelium
- Fluorescent Antibody Technique
- Humans
- Hyperplasia
- Immunohistochemistry
- Keratins
- Membrane Proteins
- Middle Aged
- Mutation
- Nasal Mucosa