Article
Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase.
The Journal of biological chemistry - 8 Mar 2002
Yoon Young-Mee, Kim Song-Ja, Oh Chun-Do, Ju Jung-Won, Song Woo Keun, Yoo Yung Joon, Huh Tae-Lin, Chun Jang-Soo
Abstract excerpt
The differentiated phenotype of chondrocyte is rapidly lost during in vitro culture by a process designated "dedifferentiation." In this study, we investigate the roles of protein kinase C (PKC) and extracellular signal-regulated protein kinase (ERK) in the maintenance of the differentiated chondrocyte phenotype. Chondrocytes isolated from rabbit articular cartilage underwent dedifferentiation upon serial...
Topics
- Animals
- Blotting, Northern
- Blotting, Western
- Cadherins
- Cartilage, Articular
- Cell Differentiation
- Cells, Cultured
- Chondrocytes
- Collagen
- Cytoskeletal Proteins
- Down-Regulation
- Enzyme Inhibitors
- Flavonoids