Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase.

The Journal of biological chemistry - 8 Mar 2002

Yoon Young-Mee, Kim Song-Ja, Oh Chun-Do, Ju Jung-Won, Song Woo Keun, Yoo Yung Joon, Huh Tae-Lin, Chun Jang-Soo

Abstract excerpt

The differentiated phenotype of chondrocyte is rapidly lost during in vitro culture by a process designated "dedifferentiation." In this study, we investigate the roles of protein kinase C (PKC) and extracellular signal-regulated protein kinase (ERK) in the maintenance of the differentiated chondrocyte phenotype. Chondrocytes isolated from rabbit articular cartilage underwent dedifferentiation upon serial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha Catenin
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chondrocytes

Share to Flavonoids

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Protein Kinase C

Share to Protein Kinase C-alpha

Source

Identifiers

PMID: 11744731
DOI: 10.1074/jbc.M110608200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase.PMID 11744731Read ↗

P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.Semantic proximity Read ↗

Recent Research on Chondrocyte Dedifferentiation and Insights for Regenerative MedicineSemantic proximity Read ↗

Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes.Semantic proximity Read ↗

Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell cultureSemantic proximity Read ↗

A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypesSemantic proximity Read ↗

Identification and characterization of arginase II as a chondrocyte phenotype-specific gene.Semantic proximity Read ↗

Strategies to Modulate the Redifferentiation of ChondrocytesSemantic proximity Read ↗

Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes.Semantic proximity Read ↗

Rapid phenotypic changes in passaged articular chondrocyte subpopulations.Semantic proximity Read ↗

Cartilage tissue formation using redifferentiated passaged chondrocytes in vitro.Semantic proximity Read ↗

Optimization of chondrocyte isolation and phenotype characterization for cartilage tissue engineering.Semantic proximity Read ↗

Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.