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Article

ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging.

Proceedings of the National Academy of Sciences of the United States of America - 26 Mar 2013

Nagata Koh O, Nakada Chieko, Kasai Rinshi S, Kusumi Akihiro, Ueda Kazumitsu

Abstract excerpt

The generation of high-density lipoprotein (HDL), one of the most critical events for preventing atherosclerosis, is mediated by ATP-binding cassette protein A1 (ABCA1). ABCA1 is known to transfer cellular cholesterol and phospholipids to apolipoprotein A-I (apoA-I) for generating discoidal HDL (dHDL) particles, composed of 100-200 lipid molecules surrounded by two apoA-I molecules; however, the regulatory...

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Topics

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Share to Apolipoprotein A-I
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipoproteins, HDL

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Source

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Identifiers

PMID: 23479619
DOI: 10.1073/pnas.1220703110
PMCID: PMC3612634

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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