A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy.

doi:10.1038/tpj.2013.7

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Article

A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy.

The pharmacogenomics journal - 1 Feb 2014

Han J-Y, Lee Y-S, Shin E Soon, Hwang J-A, Nam S, Hong S-H, Ghang H Young, Kim J Young, Yoon S Jin, Lee J Soo

Abstract excerpt

We conducted a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) influencing overall survival (OS) of small-cell lung cancer (SCLC) patients. We prospectively collected blood samples from 139 SCLC patients who participated in phase II studies of irinotecan and cisplatin (IP) chemotherapy as first-line therapy. Among 334 127 SNPs, which passed quality control, seven showed...

Topics

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Camptothecin
Cisplatin
Clinical Trials, Phase II as Topic
Data Interpretation, Statistical
Disease-Free Survival
Female
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Irinotecan

Lung Neoplasms

Male

Middle Aged

Polymorphism, Single Nucleotide

Predictive Value of Tests

Prospective Studies

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Open in PubMed

Identifiers

PMID: 23478653
DOI: 10.1038/tpj.2013.7

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