Article
MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer.
Oncotarget - 19 Apr 2016
Jiang Wei, Bi Nan, Zhang Wen-Jue, Wu Li-Hong, Liu Li-Pin, Men Yu, Wang Jing-Bo, Liang Jun, Hui Zhou-Guang, Zhou Zong-Mei, Wang Lu-Hua
Abstract excerpt
We examined the impact of single nucleotide polymorphisms (SNPs) at miRNA binding sites in the 3'-UTRs of genes in the apoptosis pathway on the prognosis of patients with limited disease-small cell lung cancer (LD-SCLC). Twelve tagSNPs in seven genes were genotyped using blood samples from 146 LD-SCLC patients treated with chemoradiotherapy. Cox proportional hazard regression models and recursive partitioning...
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