Article
Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.
Molecular cancer research : MCR - 1 May 2014
Rogers Michael S, Novak Katherine, Zurakowski David, Cryan Lorna M, Blois Anna, Lifshits Eugene, Bø Trond H, Oyan Anne M, Bender Elise R, Lampa Michael, Kang Soo-Young, Naxerova Kamila, Kalland Karl-Henning, Straume Oddbjorn, Akslen Lars A, Watnick Randolph S, Folkman Judah, Naumov George N
Abstract excerpt
UNLABELLED: The angiogenic switch, a rate-limiting step in tumor progression, has already occurred by the time most human tumors are detectable. However, despite significant study of the mechanisms controlling this switch, the kinetics and reversibility of the process have not been explored. The stability of the angiogenic phenotype was examined using an established human liposarcoma xenograft model....
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