Article
Mutant MCP-1 therapy inhibits tumor angiogenesis and growth of malignant melanoma in mice.
Biochemical and biophysical research communications - 11 Jan 2008
Koga Mitsuhisa, Kai Hisashi, Egami Kimiyasu, Murohara Toyoaki, Ikeda Ayami, Yasuoka Suguru, Egashira Kensuke, Matsuishi Toyojiro, Kai Mamiko, Kataoka Yasufumi, Kuwano Michihiko, Imaizumi Tsutomu
Abstract excerpt
We investigated whether blocking of monocyte chemoattractant-1 (MCP-1) function would inhibit recruitment of tumor-associated macrophages (TAMs) and prevent tumor angiogenesis and tumor growth of human malignant melanoma. B16-F1 melanoma cells were implanted onto the back of C57BL/6 mice (Day 0). At Day 7, a dominant negative MCP-1 mutant (7ND) gene was transfected in the thigh muscle to make overexpressed 7ND...
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