Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2013

Calvert Richard J, Gupta Meghana, Maciag Anna, Shiao Yih-Horng, Anderson Lucy M

Abstract excerpt

The K-ras gene is frequently mutated in lung and other cancers. K-ras protein includes two splice variants, K-ras 4A and 4B. While K-ras 4B is more widely expressed, recent evidence implicates K-ras 4A in lung tumorigenesis. We found that K-ras 4A protein has a wide range of expression in a large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutant Proteins

Share to Protein Isoforms

Share to Proto-Oncogene Proteins p21(ras)

Share to RNA, Small Interfering

Share to Superoxides

Source

Open in PubMed Open full text

Identifiers

PMID: 23474128
DOI: 10.1016/j.lungcan.2013.01.022
PMCID: PMC3992873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23474128-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.PMID 23474128Read ↗

A cross-sectional study examining the expression of splice variants K-RAS4A and K-RAS4B in advanced non-small-cell lung cancer patients.Semantic proximity Read ↗

Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells.Semantic proximity Read ↗

Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-αSemantic proximity Read ↗

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.Semantic proximity Read ↗

Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.Semantic proximity Read ↗

Regulation of pancreatic cancer growth by superoxideSemantic proximity Read ↗

Analysis of Mutations in K-ras and p53 Genes in Sputum and Plasma Samples.Semantic proximity Read ↗

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.Semantic proximity Read ↗

K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation.Semantic proximity Read ↗

Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.Semantic proximity Read ↗

Analysis of K-RAS and P53 mutations in sputum samples.Semantic proximity Read ↗

Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.