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Article

A cross-sectional study examining the expression of splice variants K-RAS4A and K-RAS4B in advanced non-small-cell lung cancer patients.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2018

Aran Veronica, Masson Domingues Pedro, Carvalho de Macedo Fabiane, Moreira de Sousa Carlos Augusto, Caldas Montella Tatiane, de Souza Accioly Maria Theresa, Ferreira Carlos Gil

Abstract excerpt

OBJECTIVES: Mammalian cells differently express 4 RAS isoforms: H-RAS, N-RAS, K-RAS4A and K-RAS4B, which are important in promoting oncogenic processes when mutated. In lung cancer, the K-RAS isoform is the most frequently altered RAS protein, being also a difficult therapeutic target. Interestingly, there are two K-RAS splice variants (K-RAS4A and K-RAS4B) and little is known about the role of K-RAS4A. Most...

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PMID: 29413054
DOI: 10.1016/j.lungcan.2017.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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