N-WASP Is Required for Stabilization of Podocyte Foot Processes

Abstract excerpt

Alteration of cortical actin structures is the common final pathway leading to podocyte foot process effacement and proteinuria. The molecular mechanisms that safeguard podocyte foot process architecture and maintain the three-dimensional actin network remain elusive. Here, we demonstrate that neuronal Wiskott-Aldrich syndrome protein (N-WASP), which promotes actin nucleation, is required to stabilize podocyte...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Renal and related cancers
• Share to Renal Diseases and Glomerulopathies
• Share to Reproductive Biology and Fertility