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Article

N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.

Nature cell biology - 24 Jul 2011

Kovacs Eva M, Verma Suzie, Ali Radiya G, Ratheesh Aparna, Hamilton Nicholas A, Akhmanova Anna, Yap Alpha S

Abstract excerpt

N-WASP is a major cytoskeletal regulator that stimulates Arp2/3-mediated actin nucleation. Here, we identify a nucleation-independent pathway by which N-WASP regulates the cytoskeleton and junctional integrity at the epithelial zonula adherens. N-WASP is a junctional protein whose depletion decreased junctional F-actin content and organization. However, N-WASP (also known as WASL) RNAi did not affect junctional...

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Source

Identifiers

PMID: 21785420
DOI: 10.1038/ncb2290

Genes

WASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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