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Article

Foothold of NPHS2 mutations in primary nephrotic syndrome.

Journal of postgraduate medicine - 1 Jan 2000

Jaffer A T, Ahmed W U, Raju D S, Jahan P

Abstract excerpt

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their most prominent features are interdigitated foot processes with filtration slits in between. These are bridged by the slit diaphragm, which plays a major role in establishing the selective permeability of the glomerular filtration barrier. We searched Medline and Pubmed using the combination of keywords "NPHS2", "podocin",...

Read the complete abstract on PubMed

Topics

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Share to NPHS2 gene
Share to Intracellular Signaling Peptides and Proteins
Share to Kidney Glomerulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Mutation

Share to Nephrotic Syndrome

Share to Podocytes

Source

Identifiers

PMID: 22120861
DOI: 10.4103/0022-3859.90083

Genes

NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Foothold of NPHS2 mutations in primary nephrotic syndrome.PMID 22120861Read ↗

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Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

Genetics of nephrotic syndrome: connecting molecular genetics to podocyte physiologySemantic proximity Read ↗

Podocyte Biology and the Emerging Understanding of Podocyte DiseasesSemantic proximity Read ↗

Regulation of the Actin Cytoskeleton in Podocytes.Semantic proximity Read ↗

A critical role of the podocyte cytoskeleton in the pathogenesis of glomerular proteinuria and autoimmune podocytopathiesSemantic proximity Read ↗

NPHS2 (Podocin) mutations in nephrotic syndrome. Clinical spectrum and fine mechanisms.Semantic proximity Read ↗

The genetic basis of FSGS and steroid-resistant nephrosis.Semantic proximity Read ↗

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

Novel NPHS2 variant in patients with familial steroid-resistant nephrotic syndrome with early onset, slow progression and dominant inheritance pattern.Semantic proximity Read ↗

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