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Article

N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier

26 Jun 2014

Abstract excerpt

During spermatogenesis, the blood-testis barrier (BTB) segregates the adluminal (apical) and basal compartments in the seminiferous epithelium, thereby creating a privileged adluminal environment that allows post-meiotic spermatid development to proceed without interference of the host immune system. A key feature of the BTB is its continuous remodeling within the Sertoli cells, the major somatic component of the...

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PMID: 24967734
DOI: 10.1371/journal.pgen.1004447

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